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Chem Commun 48:1099610998

The FDA has approved six drugs for the long-term treatment of obesity, Contrave (bupropion and naltrexone), Saxenda (liraglutide), Xenical and Alli (orlistat), Qsymia (phentermine and topiramate), Wegovy (semaglutide), and Imcivree (setmelanotide) [43, 45]

Quick Answer: Wegovy does not directly cause coldness, but patients commonly feel colder due to weight loss reducing body fat insulation and lowering metabolic heat production